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Lists

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unordered list:

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Nested lists

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  1. three

unordered list:

    • one
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Legislative lists

ordered list:

  1. one
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Image fractions

Number - fractions

Pupils should be taught to:

  • recognise, find, name and write fractions 1/3 , 1/4 , 2/4 and 3/4 of a length, shape, set of objects or quantity
  • write simple fractions, for example 1/2 of 6 = 3 and recognise the equivalence of 2/4 and 1/2

Notes and guidance (non-statutory)

Pupils use fractions as ‘fractions of’ discrete and continuous quantities by solving problems using shapes, objects and quantities. They connect unit fractions to equal sharing and grouping, to numbers when they can be calculated, and to measures, finding fractions of lengths, quantities, sets of objects or shapes. They meet 3/4 as the first example of a non-unit fraction.

Pupils should count in fractions up to 10, starting from any number and using the 1/2 and 2/4 equivalence on the number line (for example, 1 1/4 , 1 2/4 (or 1 1/2 ), 1 3/4 , 2). This reinforces the concept of fractions as numbers and that they can add up to more than 1.

Text fractions

If an image is not available for a particular fraction, then we'll fallback to text based fraction using sup/sub, like this 1100 example.

Blockquote

My quote

about things

Tables

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Heading 1 Heading 2
cell 1 cell 2
cell 3 cell 4

Charts

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row 1 10
row 2 15

Address

First line of address
Second line of address
75 This street
United Kindom
Phone: 07123456789

Addresses are generated when using the `$A` markdown pattern.

Contact

Media enquiries

2 Marsham Street
London

SW1P 4DF

A comment about the contact

Contact with surrounding text

This is a title

Media enquiries

2 Marsham Street
London

SW1P 4DF

A comment about the contact

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Media enquiries

2 Marsham Street
London

SW1P 4DF

A comment about the contact

Footnotes

This is a text with a footnote1.

  1. And here is the definition.

Rtl content

قال وزير الخارجية، ويليام هيغ:

مع بدء هذا الشهر الفضيل أتمنى للمسلمين في أنحاء العالم - في آسيا وأفريقيا والشرق الأوسط وأوروبا وغيرها من مناطق العالم - شهر رمضان مبارك.

في المملكة المتحدة يُحتفل بشهر رمضان منذ أجيال عديدة، ونفتخر بروابطنا القوية مع العالم الإسلامي، سواء مع شركائنا المعهودين في الشرق الأوسط أو روابطنا التاريخية المتينة في آسيا وأفريقيا أو مواطنينا المسلمين البريطانيين المفعمين بالحيوية والنشاط.

ordered list

  1. تابع الوزير أليستر بيرت عبر تويتر
  2. تابعنا باللغة العربية عبر
  3. تابعنا باللغة العربية عبر تويتر

unordered list

  • تابع الوزير أليستر بيرت عبر تويتر
  • تابعنا باللغة العربية عبر
  • تابعنا باللغة العربية عبر تويتر

With bold unstyled

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With rich govspeak

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With youtube embed

This content has a YouTube video link, converted to an accessible embedded player by component JavaScript.

Operations: a developer's guide, by Anna Shipman

With youtube embed disabled

This content has a YouTube video link, where the govspeak expansion has been disabled

Operations: a developer's guide, by Anna Shipman

Statistic headlines

This includes £5.8 billion Resource DEL and £0.2 billion Capital DEL. In addition, DWP Annually Managed Expenditure (AME) in financial year 2015 to 2016 is £170.5 billion, as forecast by the Office for Budget Responsibility.

Specialist content

Bisphosphonates

Bisphosphonates are used to treat osteoporosis, Paget’s disease, and as part of some cancer regimens, particularly for metastatic bone cancer and multiple myeloma. Individual bisphosphonates have different indications (see individual Summaries of Product Characteristics1). The following bisphosphonates are available in the UK:

  • Alendronic acid
  • Ibandronic acid
  • Pamidronate disodium
  • Risedronate sodium
  • Sodium clodronate
  • Zoledronic acid

Osteonecrosis of the external auditory canal

Benign idiopathic osteonecrosis of the external auditory canal is a rare condition that can occur in the absence of antiresorptive therapy and is sometimes associated with local trauma.

Advice for healthcare professionals:

  • The possibility of osteonecrosis of the external auditory canal should be considered in patients receiving bisphosphonates who present with ear symptoms, including chronic ear infections, or in patients with suspected cholesteatoma
  • Possible risk factors include steroid use and chemotherapy, with or without local risk factors such as infection or trauma
  • Patients should be advised to report any ear pain, discharge from the ear, or an ear infection during bisphosphonate treatment
  • Report any cases of osteonecrosis of the external auditory canal suspected to be associated with bisphosphonates or any other medicines, including denosumab, on a Yellow Card

Evidence for an association with bisphosphonate treatment

Evidence from the clinical literature and from cases reported to medicines regulators, including one report received via the UK Yellow Card scheme, supports a causal association between bisphosphonates and osteonecrosis of the external auditory canal. Product information is being updated to include advice for healthcare professionals and patients.

A total of 29 reports indicative of osteonecrosis of the external auditory canal in association with bisphosphonates have been identified worldwide, including 11 cases reported in the clinical literature.2 3 4 5 6 7 8 Cases have been reported with use of both intravenous or oral bisphosphonates for both cancer-related or osteoporosis indications; there is currently insufficient evidence to determine whether there is any increased risk with higher doses used for cancer-related conditions. Most cases were associated with long-term bisphosphonate therapy for 2 years or longer, and most cases had possible risk factors including: steroid use; chemotherapy; and possible local risk factors such as infection, an ear operation, or cotton-bud use. Bilateral osteonecrosis of the external ear canal was reported in some patients, as was osteonecrosis of the jaw.

The number of cases of osteonecrosis of the external auditory canal reported in association with bisphosphonates is low compared with the number of cases reported of bisphosphonate-related osteonecrosis of the jaw, a well-established side effect of bisphosphonates.9

Evidence for an association with denosumab treatment

The available data do not support a causal relation between osteonecrosis of the external auditory canal and denosumab. However, this possible risk is being kept under close review, given that denosumab is known to be associated with osteonecrosis of the jaw.

Article citation: Drug Safety Update volume 9 issue 5 December 2015: 3.

  1. Summaries of Product Characteristics can be found here on the MHRA website or on the website of the European Medicines Agency, depending whether the medicine has a national or European licence, respectively.

  2. Bast F, et al. Bilateral bisphosphonate-associated osteonecrosis of the external ear canal: a rare case. HNO. 2012; 60: 1127–29 [in German].

  3. Froelich K, et al. Bisphosphonate-induced osteonecrosis of the external ear canal: a retrospective study. Eur Arch Otorhinolaryngol 2011; 268: 1219–25.

  4. Kharazmi M, et al. Bisphosphonate-associated osteonecrosis of the auditory canal. Br J Oral Maxillofac Surg 2013; 51: e285–87.

  5. Polizzotto MN, et al. Bisphosphonate-associated osteonecrosis of the auditory canal. Br J Haematol 2006; 132: 114.

  6. Salzman R, et al. Osteonecrosis of the external auditory canal associated with oral bisphosphonate therapy: case report and literature review. Otol Neurotol 2013; 34: 209–13.

  7. Thorsteinsson AL, et al. Bisphosphonate-induced osteonecrosis of the external auditory canal: a case report. J Clin Med Case Reports 2015; 2: 3.

  8. Wickham N, et al. Bisphosphonate-associated osteonecrosis of the external auditory canal. J Laryngol Otol 2013; 127 (suppl 2): S51–53.

  9. Patient reminder cards about the risk of osteonecrosis of the jaw are being introduced for intravenous bisphosphonates and denosumab. The cards will become available at different times for individual products. They are now available for the following products: Prolia (denosumab); Xgeva (denosumab); Aclasta (zoledronic acid); Zometa (zoledronic acid); zoledronic acid 5 mg generics and zoledronic acid 4 mg generics. The cards can be viewed here.

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Fly-tipping incidents and actions reported by local authorities in 2014 to 2015

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If you use assistive technology and need a version of this document in a more accessible format, please email defra.helpline@defra.gsi.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

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مستقبل الغذاء والزراعة: موجز تنفيذي

هذا المف قد لا يكون مناسبا لمستخدمي التكنولوجيا المساعدة على القراءة

لاستلام وثيقة مكتوبة بشكل آخر، كلغة بريل أو وثيقة صوتية أو أي نوع آخر من الوثائق، يرجى إرسال رسالة إلكترونية إلى enquiries@bis.gsi.gov.uk مع كتابة عنوانك ورقم هاتفك إلى جانب عنوان الوثيقة المطلوبة ("{title}"), and its reference (Unique reference: BIS/11/924)

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If you drilled a tunnel straight through the Earth and jumped in, it would take you exactly 42 minutes and 12 seconds to get to the other side.

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The water in the mouth of a blue whale weighs more than its body.

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The VAT rate is 20%

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